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Coumarin-Induced Skin Necrosis Following Heparin-Induced Thrombocytopenia and Thrombosis A Case Report

Emoke Posan

Gabriella Szücs

Janos Rigo

Zoltan Boda

A severe thrombotic thrombocytopenic status, induced by heparin in a sixty-nine-year-old woman undergoing total hip joint arthroplasty, was treated by switching the anticoagu lant therapy to coumarin, which induced skin necrosis. There appeared to be a possible causal relation between the severe immune reaction to heparin and the condition that predisposed to skin necrosis in the presence of coumarin. In patients who express a strong immune response to heparin, a different anticoagulant approach other than use of coumarin congeners appears to be justified..

Angiology, Vol. 47, No. 7, 725-727 (1996)
DOI: 10.1177/000331979604700715


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