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Angiology
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Arachidonic Acid Metabolites in Acute Myocardial Infarction

Bonpei Takase

1st Department of Internal Medicine, National Defense Medical College, Saitama

Toshiharu Maruyama

1st Department of Internal Medicine, National Defense Medical College, Saitama

Akira Kurita

1st Department of Internal Medicine, National Defense Medical College, Saitama

Akimi Uehata

1st Department of Internal Medicine, National Defense Medical College, Saitama

Toshihiko Nishioka

1st Department of Internal Medicine, National Defense Medical College, Saitama

Kyoichi Mizuno

1st Department of Internal Medicine, National Defense Medical College, Saitama

Haruo Nakamura

1st Department of Internal Medicine, National Defense Medical College, Saitama

Kenichiro Katsura

1st Department of Internal Medicine, National Defense Medical College, Saitama

Yoshikazu Kanda

2nd Department of Biochemistry, Nippon Medical School, Tokyo, Japan

Abnormalities of arachidonic acid metabolism are implicated in spasm and thrombosis in coronary arteries. Therefore, arachidonic acid metabolites were examined in patients with acute myocardial infarction (AMI). Plasma levels of thromboxane B2 (TXB 2), 6-keto prostaglandin F1{alpha} (6KPGF1{alpha}), leukotriene B4 (LTB4), and slow reacting substance of anaphylaxis (SRS-A) composed of leukotriene C4 (LTC4), leukotriene D4 (LTD4) and leukotriene E4 (LTE4), were measured in 19 AMI patients. Plasma levels of TXB2, LTB4, and SRS-A in systemic artery blood were significantly elevated during the acute stage (within twenty-four hours after the onset of chest pain) of AMI (TXB2, 0.36 ng/mL; LTB4, 0.75 ng/mL; and SRS-A [LTC4+LTD4+LTE 4], 0.96 ng/mL) compared with those of normal controls (TXB2, 0.18 ng/mL; LTB4, 0.44 ng/mL; and SRS-A [LTC4+LTD4+LTE 4], 0.31 ng/mL). These values decreased to near-normal control levels by one month after the AMI attack. The findings in this study suggest that abnormalities of arachidonic acid metabolism accompany, and may play a role in the pathogenesis of, AMI.

Angiology, Vol. 47, No. 7, 649-661 (1996)
DOI: 10.1177/000331979604700703
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