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Angiology
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Angiotensin-Converting Enzyme Gene Polymorphism in Essential Hypertensive Patients in Japanese Population

Motofumi Maguchi

2nd Department of Internal Medicine, Ehime University School of Medicine, Japan

Katsuhiko Kohara

2nd Department of Internal Medicine, Ehime University School of Medicine, Japan

Takafumi Okura

2nd Department of Internal Medicine, Ehime University School of Medicine, Japan

Shimin Li

2nd Department of Internal Medicine, Ehime University School of Medicine, Japan

Masayuki Takezaki

2nd Department of Internal Medicine, Ehime University School of Medicine, Japan

Wataru Nishida

2nd Department of Internal Medicine, Ehime University School of Medicine, Japan

Kunio Hiwada

2nd Department of Internal Medicine, Ehime University School of Medicine, Japan

Association between angiotensin-converting enzyme (ACE) gene polymorphism and essential hypertension in a Japanese population with the same socioeconomic back ground was investigated. Insertion-deletion (I/D) polymorphism of the ACE gene located on intron 16 was detected by polymerase chain reaction. Association between ACE gene polymorphism and family history of essential hypertension as well as the development of vascular damage in eye fundi were also investigated. Variation at ACE loci did not contribute to essential hypertension and the vascular damages in eye fundi. These results suggested that the ACE gene was not directly responsible for essential hypertension in this particular Japanese population with the same socioeconomic background.

Angiology, Vol. 47, No. 7, 643-648 (1996)
DOI: 10.1177/000331979604700702
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