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Acute Exposure to Carbon Monoxide Does Not Affect Plasma Lipids, Lipoproteins, and Apolipoproteins

Department of Medicine, School of Medicine, University of California, Los Angeles and West Los Angeles Veterans Administration Medical Center

Michael T. Kleinman, Ph.D.

Department of Community and Environmental Medicine, University of California, Irvine

Study objectives: To examine the effects of acute exposure to carbon monoxide and hypoxia on plasma lipids, lipoproteins, and apolipoproteins. Design: Random-order assignment to blinded, inhaled exposures of carbon monoxide and hypoxia. Setting: Research laboratory of ambulatory subjects. Subjects: 10 elderly, male nonsmokers with chronic stable angina. Intervention: Random-order two-hour inhaled exposure to clean air at sea level, carbon monoxide at sea level, carbon monoxide at high altitude, and clean air at high altitude. Measurements: Fasting plasma lipids, lipoproteins, and apolipoproteins before and after exposures.

Results: No differences were noted between fasting plasma lipid, lipoprotein, or apolipoprotein levels before and after exposures. Conclusion: Acute exposure to carbon monoxide and high altitude does not affect fasting plasma lipid, lipoprotein, or apolipoprotein levels.

Angiology, Vol. 47, No. 4, 337-341 (1996)
DOI: 10.1177/000331979604700403


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