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Jaundice Induced by Streptokinase

Cardiology Division, Soroka Medical Center, and Faculty of Health Sciences, Ben Gurion University, Beer Sheva, Israel

Gisela Cohn, M.D.

Cardiology Division, Soroka Medical Center, and Faculty of Health Sciences, Ben Gurion University, Beer Sheva, Israel

Alexander Battler, M.D.

Cardiology Division, Soroka Medical Center, and Faculty of Health Sciences, Ben Gurion University, Beer Sheva, Israel

Streptokinase is the mainstream therapy for acute myocardial infarction. A fifty-seven-year-old man with acute MI was admitted to the intensive cardiac care unit and received streptokinase and heparin. At the time of admission, he was not receiving any drugs and denied any previous exposure to a hepatotoxic agent. Five hours later, he developed a dramatic hypersensitivity reaction including high fever, pulmonary edema, cyanosis, and convulsions. Within twelve hours, his clinical state was stabilized. After forty-eight hours, he developed jaundice and transaminasemia, which subsided by the eighth day. Only a few reports of overt jaundice are associated with streptokinase.

Angiology, Vol. 47, No. 3, 281-284 (1996)
DOI: 10.1177/000331979604700310


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