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Prospective Study of Vascular Events and Cerebral Perfusional Chang Following Transient Ischemic Attacks

Cerebral Blood Flow Laboratory, Veterans Affairs Medical Center, Department of Neurolc Baylor College of Medicine, Houston, Texas

John S. Meyer, M.D., F.A.C.A.

Cerebral Blood Flow Laboratory, Veterans Affairs Medical Center, Department of Neurolc Baylor College of Medicine, Houston, Texas

A prospective case-control study was carried out to clarify associations of cerebr transient ischemic attacks (TIAs) and other stroke risk factors with progression and exa erbation of cardiovascular and cerebrovascular disorders; 243 neurologically norm controls and 123 TIA patients without prior history of stroke were followed up for mean interval of 4.4 years. Of TIA patients, 26 (21%) developed other events (excludi recurrent TIAs); 10 died of vascular causes (8.1%). Of controls, 44 (18%) develope events; 13 died of vascular causes (5.4%) and 3 from cancer. TIA patients were at 2 times greater risk than normal controls for stroke or death from vascular causes. The were predominantly male with significantly higher associations of risk factors for strok including hypertension, heart disease, diabetes mellitus, smoking, hyperlipidemia, alcoh consumption, and limited education. Controls developing vascular events compared wi controls who did not were older, more frequently male, and with greater incidences heart disease. TIA patients had lower rates of cerebral perfusion compared with contro that persisted throughout the study, with similar rates of decline related to aging amor both groups. Among TIA patients, stroke risk factors were more prevalent than amor controls. The longer their duration, the greater the incidence and the more rapid the rate of severe often fatal cardiovascular complications

Angiology, Vol. 47, No. 3, 215-224 (1996)
DOI: 10.1177/000331979604700301


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