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Postphlebitic Syndrome: Clinical Activity and Tolerability of Desmin, New LMW Dermatan Sulfate

Department of Internal Medicine, "A. Francaviglia," Chair of Angiology, University of Catania

Salvatore Signorelli

Department of Internal Medicine, "A. Francaviglia," Chair of Angiology, University of Catania

Luigi Di Pino

Department of Internal Medicine, "A. Francaviglia," Chair of Angiology, University of Catania

Claudio Allegra

Department of Angiology, "S. Giovanni Addolorata" Hospital, Rome

Camillo Riccioni

Department of Angiology, "S. Giovanni Addolorata" Hospital, Rome

Domenico Cucinotta

Ward of Geriatric Medicine, "S. Orsola-Malpighi" Hospital, Bologna

Roberto Manopulo

Ward of Geriatric Medicine, "S. Orsola-Malpighi" Hospital, Bologna

Anton Giulio Dettori

Center of Hemostatic Disease, "Maggiore" Hospital, Parma

Alessandro Megha

Center of Hemostatic Disease, "Maggiore" Hospital, Parma

Franco Nicola Longo

Department of Angiology, "Piemonte" Hospital, Messina, Department of First Medical Clinic, University of Messina

Oreste Urbano

Department of Angiology, "Piemonte" Hospital, Messina, Department of First Medical Clinic, University of Messina

Agatino Manganaro

Department of Angiology, "Piemonte" Hospital, Messina, Department of First Medical Clinic, University of Messina

Domenico Buda

Department of Angiology, "Piemonte" Hospital, Messina, Department of First Medical Clinic, University of Messina

Villiam Zamboni

Medical Department, Alfa Wassermann S.p.A., Bologna, Italy

Ernesto Palazzini

Medical Department, Alfa Wassermann S.p.A., Bologna, Italy

One hundred patients suffering from postphlebitic syndrome of the lower limbs were enrolled in an open, randomized, and multicenter (six centers) trial for a period of eighteen months. Patients were randomly assigned to three treatment groups to receive (for ninety consecutive days) Desmin, a new low-molecular-weight dermatan sulfate, at the dose, respectively, of 100 mg once daily by subcutaneous (SC) route (36 patients), 100 mg twice a day by SC route (33 patients), and 200 mg once daily by intramuscular (IM) route (31 patients). The general and local tolerability and the clinical efficacy of the drug were evaluated by means of clinical, instrumental, and laboratory parameters. Desmin is effective in the decompensation stage of postphlebitic syndrome; this was demonstrated by a significant reduction in the severity of a number of typical symptoms as well as by the drug's positive effect on venous tone as confirmed by phlebotensio metric examination. The daily dose of 200 mg (either SC or IM) was more effective than the 100 mg dose. The results obtained at the end of the trial (ninety days) were statisti cally better than those obtained after thirty days of treatment.

This trial demonstrated that both the systemic and the local (at the site of injection) tolerability of the drug, administered for three months, were good and without significant variations in the laboratory parameters monitored.

Angiology, Vol. 47, No. 10, 1001-1010 (1996)
DOI: 10.1177/000331979604701009


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