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Intimal Medial Thickening of Common Carotid Artery as Indicator of Coronary Artery Disease

Department of Internal Medicine, University of Padova

Raffaele Pesavento, M.D.

Department of Internal Medicine, University of Padova

Luigi Lusiani, M.D.

Department of Internal Medicine, University of Padova

Andrea Bonanome, M.D.

Department of Internal Medicine, University of Padova

Carlo Cernetti, M.D.

Department of Internal Medicine, University of Padova

Maurizio Rossi, M.D.

Department of Cardiology, Cittadella Hospital, Padua, Italy

Pietro Maiolino, M.D.

Department of Cardiology, Cittadella Hospital, Padua, Italy

Antonio Pagnan, M.D.

Department of Internal Medicine, University of Padova

The authors investigated the relation between coronary atherosclerosis, angiographically detected, and intimal-medial (I-M) thickening of the common carotid artery (CCA), as measured by high-resolution B-mode ultrasound system. They studied 31 patients with coronary artery disease (CAD) and 23 healthy control subjects. I-M thickening of CCAs and atheromatous plaques at the carotid bifurcation were evaluated. A score system was defined (range 0-20) based on the absence or presence of atherosclerotic lesions at common and internal carotid arteries. A coronary angiography score was defined based on the presence of atherosclerotic lesions at nine coronary arterial segments (range 0-36) .

The thickness of CCAs (M ±SD) in CAD patients was significantly higher (1.45 ±0.95 mm) than in controls (0.87 ±0.10 mm, P < 0.005), and an I-M thickening of 1.1 mm or more was specific and positively predictive of CAD. A significant positive correlation between coronary and carotid score was observed (P < 0.028, r=0.373).

The study suggests that I-M thickening could be helpful for the identification of patients at risk for CAD.

Angiology, Vol. 47, No. 1, 61-66 (1996)
DOI: 10.1177/000331979604700109


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