SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
Angiology
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Piette, L. H.
Right arrow Articles by Zhang, W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Piette, L. H.
Right arrow Articles by Zhang, W.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Failure to Detect Free Radicals in the Isolated Perfused Rat Heart

Lawrence H. Piette, Ph.D.

Cardiovascular Research Laboratory, John A. Burns School of Medicine, The Queen's Medical Center, Honolulu, Hawaii, Department of Chemistry and Biochemistry, Utah State University, Logan, Utah

J. Judson McNamara, M.D., F.A.C.S., F.A.C.C.

Department of Surgery, John A. Burns School of Medicine, The Queen's Medical Center, Honolulu, Hawaii

Shyamal Premaratne, M.D., Ph.D.

Department of Surgery, John A. Burns School of Medicine, The Queen's Medical Center, Honolulu, Hawaii

Wei Zhang, M.D.

Cardiovascular Research Laboratory, John A. Burns School of Medicine, The Queen's Medical Center, Honolulu, Hawaii, Department of Chemistry and Biochemistry, Utah State University, Logan, Utah

Oxygen free radicals have been indirectly implicated in reperfusion injury following ischemia in the isolated rabbit heart. The authors moved to detect free radicals in an isolated rat heart model as a prerequisite to studying its effects during ischemia and reperfusion. Several different spin trapping agents and electron paramagnetic resonance (EPR) spectroscopy were used to detect free radicals being generated during ischemia and reperfusion. The possible roles of ferrous iron and hydrogen peroxide generation in reperfusion injury were also investigated. No free radical "bursts" were detected with any of the spin traps used in this model during ischemia or reperfusion. Hydrogen peroxide and hydroxyl free radicals do not appear to be involved in tissue reperfusion injury. This study suggests that free radicals are not produced in clinically significant quantities under these conditions to account for ischemic myocardial damage.

Angiology, Vol. 47, No. 1, 1-7 (1996)
DOI: 10.1177/000331979604700101
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?




Advertisement