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Dynamic Exercise Induces Elevation of Plasma Levels of Endothelin-1 in Patients with Coronary Artery Disease

Medical Pathology I, University of Rome "La Sapienza,"

F. Barillà

Department of Cardiology, University of Rome "La Sapienza," Italy

S. Cerci

Medical Pathology I, University of Rome "La Sapienza,"

C. D'Ambrosio

Medical Pathology I, University of Rome "La Sapienza,"

S. Coassin

Medical Pathology I, University of Rome "La Sapienza,"

A. De Ciocchis

Medical Pathology I, University of Rome "La Sapienza,"

M.A. Mastroianni

Department of Cardiology, University of Rome "La Sapienza," Italy

P.P. Campa

Department of Cardiology, University of Rome "La Sapienza," Italy

D. Scavo

Medical Pathology I, University of Rome "La Sapienza,"

In this investigation the response of endothelin-1 plasma levels to dynamic exercise in patients with coronary artery disease (CAD) was studied. The study population consisted of 20 patients with CAD, 16 men and 4 women (mean age 53 ±8.6 years). Seven normal volunteers all men (mean age 53.4 ±4.4 years) were studied as a control group. Seven patients had prior myocardial infarction. All patients and controls exercised on a multi stage bicycle ergometer; plasma endothelin-1 levels and hemodynamic indices were measured at rest, at peak exercise, and at two and six minutes after exercise. Of the 20 patients examined, 7 (35%) showed electrocardiographic (ECG) signs of myocardial ischemia during the stress test. The mean plasma endothelin-1 concentration increased significantly from 7.8 ±3.0 to 13.6 ±3.5 pg/mL at exercise peak (P < 0.05) only in patients who did not show ECG signs of myocardial ischemia and returned to baseline values during recovery (six minutes) (9.4 ±2.1 pg/mL). In normal subjects baseline endothelin-1 levels (9.4 ±4.2 pg/mL) were not significantly altered at peak exercise (10.8 ±4.7 pg/mL) and at recovery (11.3 ±3.6 pg/mL). The hemodynamic parameters were not correlated with the plasma endothelin-1 levels before, during, and after exercise in all groups.

The present study demonstrated that the plasma levels of endothelin-1 in patients with CAD increased significantly during stress testing.

Angiology, Vol. 46, No. 9, 819-826 (1995)
DOI: 10.1177/000331979504600908


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