This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Bridges, A.B. Articles by Belch, J.J.F. Search for Related Content PubMed PubMed Citation Articles by Bridges, A.B. Articles by Belch, J.J.F. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB CAPTOPRIL ENALAPRIL MALEATE Medline Plus Health Information Heart Failure Social Bookmarking                         What's this?

A Comparative Study of Captopril and Enalapril on Endothelial Cell Function in Congestive Heart Failure Patients

Section of Vascular Medicine, University Department of Medicine, Ninewells Hospital and Medical School, Dundee, Scotland

M. McLaren

Section of Vascular Medicine, University Department of Medicine, Ninewells Hospital and Medical School, Dundee, Scotland

J.J.F. Belch

Section of Vascular Medicine, University Department of Medicine, Ninewells Hospital and Medical School, Dundee, Scotland

Angiotensin-converting enzyme (ACE) inhibitors have been shown to reduce the incidence of future coronary artery thromboses in postmyocardial infarction patients. A possible prothrombotic role for the angiotensin system has been postulated, and support for this has been provided by a recent study that demonstrated that an infusion of angiotensin increases levels of the prothrombotic plasminogen activator inhibitor (PAI).

In the current study the authors have investigated the effect of two ACE inhibitors, captopril and enalapril, on tissue plasminogen activator (tPA) and PAI in 33 congestive heart failure (CHF) patients. Blood samples were obtained pretreatment and then at weeks 1, 12, and 24 after initiation of ACE inhibitor therapy for measurement of tPA antigen and PAI activity levels.

The results of the study indicated that the initiation of ACE inhibitors had no signif icant effects on tPA antigen or PAI activity levels at the time points studied, and no signif icant differences were demonstrated between captopril and enalapril. The results suggest, therefore, that ACE inhibitors do not affect tPA antigen or PAI activity in CHF patients, and thus another mechanism is probably responsible for the observed decrease in coronary artery thromboses in post-MI patients treated with ACE inhibitors.

Angiology, Vol. 46, No. 9, 811-817 (1995)
DOI: 10.1177/000331979504600907


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?