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Vasomotor Effects of Transcutaneous CO2 in Stage II Peripheral Occlusive Arterial Disease

Département de Physiologie, UFR Biomédicale des St. Pères, Paris Cedex

Olivier Bailliart

Département de Physiologie, UFR Biomédicale des St. Pères, Paris Cedex

Philippe Bonnin

Département de Physiologie, UFR Biomédicale des St. Pères, Paris Cedex

Mario Bedu

Laboratoire d'Explorations Fonctionnelles, Hopital Sabourin, Clermont Ferrand Cedex, France

Jean Cheynel

Study performed at the Cardiovascular Research Institute, Royat, France

Jean Coudert

Laboratoire d'Explorations Fonctionnelles, Hopital Sabourin, Clermont Ferrand Cedex, France

Jean-Paul Martineaud

Département de Physiologie, UFR Biomédicale des St. Pères, Paris Cedex

Vasomotor effects of skin exposure to carbon dioxide (CO₂) have been described in normal subjects. It was of interest, therefore, to determine whether percutaneous CO₂ is of therapeutic benefit. In a randomized, double-blind study, 10 patients with lower limb arteriopathy (stage II) were investigated before and after local exposure for twenty minutes to CO₂-rich spa gas or to water-vapor-saturated air at the same temperature as that CO₂ -rich spa gas.

Brachial and femoral blood flows, brachial and posterior tibial artery pressures, heart rate, and chest and foot transcutaneous oxygen tensions (tcPO₂) were determined. Femoral blood flow, tibial pressure, and foot tcPO₂ were significantly increased after exposure of the skin to CO₂-rich spa gas. This effect was not accompanied with systemic hemodynamic modifications. Water-vapor-saturated air had no effect.

These results suggest that transfer of CO₂ across the skin can have beneficial local vasomotor effects in patients with lower limb stage II arteriopathy.

Angiology, Vol. 46, No. 9, 785-791 (1995)
DOI: 10.1177/000331979504600904


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