This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Tokgözoglu, S. L. Articles by Ugurlu, S. Search for Related Content PubMed PubMed Citation Articles by Tokgözoglu, S. L. Articles by Ugurlu, S. Social Bookmarking                         What's this?

Does Increased Lipoprotein (a) Impair the Effectiveness of Thrombolysis With Streptokinase?

S. Lale Tokgözolu

Department of Cardiology, Hacettepe University Faculty of Medicine, Ankara, Turkey

Ferhan Ozmen

Department of Cardiology, Hacettepe University Faculty of Medicine, Ankara, Turkey

Mehmet Kabukçu

Department of Cardiology, Hacettepe University Faculty of Medicine, Ankara, Turkey

Aydin Karanfil

Department of Cardiology, Hacettepe University Faculty of Medicine, Ankara, Turkey

Kudret Aytemir

Department of Cardiology, Hacettepe University Faculty of Medicine, Ankara, Turkey

Cumhur Ozkuyumcu

Department of Cardiology, Hacettepe University Faculty of Medicine, Ankara, Turkey

evket Ugurlu

Department of Cardiology, Hacettepe University Faculty of Medicine, Ankara, Turkey

Although lipoprotein (a) [Lp(a)] has been shown to interfere with thrombolysis in vitro, its effects on thrombolytic therapy in patients with acute myocardial infarction (MI) are not clear. The authors evaluated 32 male patients ages thirty-five to seventy-five (mean fifty-two ±ten) with the diagnosis of acute MI who underwent thrombolytic therapy with 1,500,000 units of intravenous streptokinase. All patients underwent coronary angio graphy within seven days of the infarction from which the thrombolysis in myocardial infarction (TIMI) flow grades of the infarct-related artery, coronary scores, and ejection fraction were determined. Anterior MI was found in 19 patients (59.4%), inferior MI in 12 (37.5%), and posterolateral MI in 1 patient (3.1%). They found that 6 patients (18.8%) had TIMI flow 0 to 1, and 26 patients (81.2%) had TIMI flow grade 2 or 3. The Lp(a) levels ranged from 0.1 to 60 mg/dL with a mean of 8.6 ±17 mg/dL. Eight (25%) of the patients had Lp(a) levels above 30 mg/dL. The TIMI flow rates were not found to be lower in patients with high Lp(a) levels (P > 0.05), and there was no significant corre lation between the TIMI flow rates and the Lp(a) levels (r=0.28). There was a good correlation between coronary scores and Lp(a) levels (r=0.87).

They conclude that although there is a good correlation between the extent of coronary atherosclerosis and Lp(a) levels, Lp(a) is not a strong predictor of the outcome of thrombolytic therapy.

Angiology, Vol. 46, No. 8, 727-731 (1995)
DOI: 10.1177/000331979504600812


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?