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Angiology
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Efficacy of Ibudilast on Lower Limb Circulation of Diabetic Patients with Minimally Impaired Baseline Flow

A Study Using Color Doppler Ultrasonography and Laser Doppler Flowmetry

Hirohito Sone

Department of Endocrinology and Metabolism, University of Tsukuba, Japan

Yukichi Okuda

Department of Endocrinology and Metabolism, University of Tsukuba, Japan

Yukari Asakura

Department of Endocrinology and Metabolism, University of Tsukuba, Japan

Michiko Asano

Department of Endocrinology and Metabolism, University of Tsukuba, Japan

Masakazu Mizutani

Department of Endocrinology and Metabolism, University of Tsukuba, Japan

Chieko Bannai

Department of Endocrinology and Metabolism, University of Tsukuba, Japan

Kamejiro Yamashita

Department of Endocrinology and Metabolism, University of Tsukuba, Japan

Ibudilast is a prostacyclin-mediated vasodilator and antiplatelet agent. The hemodynamic effects of ibudilast were evaluated in 41 patients with non-insulin-dependent diabetes mellitus by means of two-dimensional Doppler ultrasonography and laser Doppler blood flowmetry. Before and one hour after oral administration of ibudilast (10 mg), or elastase (1800 U) as a control, the cross-sectional area (CSA) of the dorsal pedis artery, its blood flow index (BFI), and dermal microcirculatory blood volume (MBV) were measured. In the ibudilast group, all of the parameters (CSA, BFI, and MBV) significantly increased as compared with the elastase group. These data suggest that ibudilast is effective in amelio rating diabetic macroangiopathy and microangiopathy of the lower limbs.

Angiology, Vol. 46, No. 8, 699-703 (1995)
DOI: 10.1177/000331979504600808
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