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Atrial Natriuretic Peptide and Antihypertensive Action Due to β-Blockade in Essential Hypertensive Patients

First Department of Internal Medicine, Kinki University School of Medicine, Osaka, Japan

Shuzou Nagata, M.D.

First Department of Internal Medicine, Kinki University School of Medicine, Osaka, Japan

Tosihiko Takenaka, M.D.

First Department of Internal Medicine, Kinki University School of Medicine, Osaka, Japan

Hirofumi Kino, M.D.

First Department of Internal Medicine, Kinki University School of Medicine, Osaka, Japan

Kouji Kamoi, M.D.

First Department of Internal Medicine, Kinki University School of Medicine, Osaka, Japan

Seijirou Shimada, M.D.

First Department of Internal Medicine, Kinki University School of Medicine, Osaka, Japan

Masatsugu Horiuchi, M.D.

First Department of Internal Medicine, Kinki University School of Medicine, Osaka, Japan

Ryo Katori, M.D.

First Department of Internal Medicine, Kinki University School of Medicine, Osaka, Japan

The effects of β-blocker treatment on hemodynamics were studied in relation to plasma atrial natriuretic peptide (ANP) levels in 17 outpatients with essential hypertension. Administration of propranolol for twelve weeks to untreated subjects resulted in a signif icant (P < 0.001) rise in plasma ANP levels (from 37.9 ±21.2 to 66.7 ±46.2 pg/mL, mean ±SD). Systolic and diastolic blood pressures were significantly decreased (P < 0.05 and P < 0.01, respectively). Heart rate was also significantly decreased (P < 0.001). On the other hand, a significant reduction of cardiac index was detected (from 4.12 ±1.34 to 2.96 ±0.75 L/min/m2, P < 0.01) with chronic administration of propranolol, suggesting a reflection of decreased cardiac function. A significant negative correlation was observed between %changes in systolic blood pressure and %changes in plasma ANP (r=-0.594, P < 0.05). These results suggest that the increased plasma ANP levels may contribute to the antihypertensive effect with propranolol.

Angiology, Vol. 46, No. 6, 511-516 (1995)
DOI: 10.1177/000331979504600608


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