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Angiology
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Contraction of Isolated Porcine Coronary Arteries is Inhibited by High Concentrations of Propranolol

Edmund L. Carey, JR., M.D.

Departments of Pharmacology and Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee

David Robertson, M.D.

Departments of Pharmacology and Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee

Jack N. Wells, Ph.D.

Departments of Pharmacology and Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee

Rose Marie Robertson, M.D.

Departments of Pharmacology and Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee

Isometric tension responses of isolated porcine coronary artery rings were studied in the presence of concentrations of propranolol higher than those necessary to block effects mediated by β-adrenergic receptors. Propranolol (50-300 µM) inhibited contractions induced by 30mM KCl and by histamine, norepinephrine, and acetylcholine in a concen tration-dependent, noncompetitive fashion. The (+) propranolol isomer and the racemic mixture were equipotent inhibitors of contraction. Propranolol inhibition was partly reversed by increased extracellular Ca++. These effects of propranolol thus appeared to be independent of β-blockade and could be relevant to some of the drug's observed but still unexplained in vivo actions.

Angiology, Vol. 46, No. 6, 453-460 (1995)
DOI: 10.1177/000331979504600601
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