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Angiology
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The Effects of Metformin on the Capillary Permeability to Albumin in Women Patients with Cyclic Edema

Paul Valensi

Service d'Endocrinologie-Diabétologie-Nutrition, Hôpital Jean Verdier, Université Paris-Nord

Abraham Behar

Service de Médecine Nucléaire, Hôpital de l'Hôtel-Dieu, Paris

Philippe Andre

Institut de Recherches Lipha, Lyon, France

Nicolas Wiernsperger

Institut de Recherches Lipha, Lyon, France

Jean-Raymond Attali

Service d'Endocrinologie-Diabétologie-Nutrition, Hôpital Jean Verdier, Université Paris-Nord

An experimental work has suggested the efficacy of metformin, an oral antidiabetic agent, on capillary permeability. This agent has been tested in 10 women patients with cyclic edema, 7 of them being obese. The capillary permeability to albumin studied by an isotope test derived from Landis's method was initially increased. After a mean of six-weeks of treatment the albumin retention and an index demonstrating the interstitial protein elimination through the lymph route were significantly improved. Concomitantly, the swelling feelings were reduced in 8 cases and the lower limb edema had decreased or disappeared in 8 of 9 patients who initially presented these symptoms. The effects of metformin are beneficial and have been observed to be independent of glycemic change. The results suggest a special effect of this agent on the microcirculation. Nevertheless, a controlled study is required.

Angiology, Vol. 46, No. 5, 401-408 (1995)
DOI: 10.1177/000331979504600506
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