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Improved Skin Blood Flow and Cutaneous Temperature in the Foot of a Patient with Arteriosclerosis Obliterans by Vasopressin V1 Antagonist (OPC21268)

A Case Report

Department of Geriatrics, Faculty of Medicine, University of Tokyo, Tokyo, Japan

Yasuyoshi Ouchi

Department of Geriatrics, Faculty of Medicine, University of Tokyo, Tokyo, Japan

Masahiro Akishita

Department of Geriatrics, Faculty of Medicine, University of Tokyo, Tokyo, Japan

Koichi Kozaki

Department of Geriatrics, Faculty of Medicine, University of Tokyo, Tokyo, Japan

Michiro Ishikawa

Department of Geriatrics, Faculty of Medicine, University of Tokyo, Tokyo, Japan

Koichiro Nagano

Department of Geriatrics, Faculty of Medicine, University of Tokyo, Tokyo, Japan

Masato Etoh

Department of Geriatrics, Faculty of Medicine, University of Tokyo, Tokyo, Japan

Masayoshi Hashimoto

Department of Geriatrics, Faculty of Medicine, University of Tokyo, Tokyo, Japan

Jing Liang

Department of Geriatrics, Faculty of Medicine, University of Tokyo, Tokyo, Japan

Namiki Ueda

Department of Geriatrics, Faculty of Medicine, University of Tokyo, Tokyo, Japan

Hajime Orimo

Department of Geriatrics, Faculty of Medicine, University of Tokyo, Tokyo, Japan

A seventy-four-year-old woman with arteriosclerosis obliterans, diabetes mellitus, and hypertension was admitted for the treatment of intermittent claudication and coldness and pain in the right lower extremity. After the administration of a vasopressin V1 antag onist, OPC21268, the symptoms were markedly improved. Furthermore, blood flow in the dorsalis pedis artery and the cutaneous temperature in the right foot increased in response to acute and chronic administration of OPC21268. OPC21268 may be a new useful therapeutic tool for the treatment of arteriosclerosis obliterans.

Angiology, Vol. 46, No. 11, 1027-1033 (1995)
DOI: 10.1177/000331979504601108


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