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Urine C-Peptide and Atherogenic Risk Factors in Diabetes Mellitus: Relevance to "Syndrome X"

Department of Internal Medicine, Saga Medical School, Saga, Japan

Toshinobu Takashima

Department of Internal Medicine, Saga Medical School, Saga, Japan

Keizo Ohmori

Department of Internal Medicine, Saga Medical School, Saga, Japan

Toshiaki Sunaga

Department of Internal Medicine, Saga Medical School, Saga, Japan

The relation between the C-peptide concentration in twenty-four-hour urine specimens and atherogenic risk factors was investigated in 38 patients with noninsulin-dependent diabetes mellitus in an attempt to determine the significance of urine C-peptide in diag nosing "syndrome X," which is characterized by insulin resistance. Weak positive corre lations between twenty-four-hour urine C-peptide concentration and body mass index, systolic blood pressure (BP), diastolic BP, serum total cholesterol, and serum triglyceride were detected. A weak negative correlation was also apparent between urine C-peptide and serum high-density lipoprotein (HDL). The body mass index and serum triglyceride of patients with urine C-peptide excretion of > 100 µg/day were significantly higher than those in patients with normal urine C-peptide excretion (< 100 µg/day) (P < 0.01 and P < 0.02, respectively). Systolic BP, diastolic BP, serum total cholesterol, and serum HDL did not differ significantly between the two groups of patients. Results indicate that twenty-four-hour urine C-peptide concentration is of significance in determining whether a patient has a tendency to insulin resistance but has only limited value as a quantitative measure of endogenous insulin secretion.

Angiology, Vol. 46, No. 10, 915-921 (1995)
DOI: 10.1177/000331979504601006


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