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Comparative Evaluation of Pentoxifylline, Buflomedil, and Nifedipine in the Treatment of Intermittent Claudication of the Lower Limbs

Cardiovascular Unit, Reina Sofia Hospital, Cordoba, Spain

M.G. Eguaras

Cardiovascular Unit, Reina Sofia Hospital, Cordoba, Spain

F. Calleja

Cardiovascular Unit, Reina Sofia Hospital, Cordoba, Spain

M.A. Garcia

Cardiovascular Unit, Reina Sofia Hospital, Cordoba, Spain

M. Roman

Cardiovascular Unit, Reina Sofia Hospital, Cordoba, Spain

J. Casares

Cardiovascular Unit, Reina Sofia Hospital, Cordoba, Spain

I. Muñoz

Cardiovascular Unit, Reina Sofia Hospital, Cordoba, Spain

M. Concha

Cardiovascular Unit, Reina Sofia Hospital, Cordoba, Spain

In the light of the current controversy surrounding the use of hemorheologic and vasodilator drugs in the treatment of peripheral arteriosclerosis, a comparative study was designed in order to evaluate the efficacy of pentoxifylline, buflomedil, and nifedipine in 45 patients with peripheral arterial disease (Fontaine stage II).

The patients in this prospective randomized study were divided into three groups: 15 patients received pentoxifylline treatment (1,200 mg/day), 15 were treated with buflomedil (600 mg/day), and 15 with nifedipine (60 mg/day).

Response to treatment was assessed at the start of the study and after forty-five and ninety days, by clinical examination, Doppler test, strain test, and digital occlusion plethysmography using a strain gauge ring. Pentoxifylline was significantly more effective (P < 0.05) than buflomedil and nifedipine at ninety days in improving walking perfor mance, resting toe pressure, resting and postexercise ankle/brachial pressure ratio, and basal/postischemic toe-pulse ratio. Significant differences within groups were also noted for initial claudication, toe peak-flow time, pulse reappearance time (PRT/2), and maximum postischemic flow time, together with significant intergroup variables. In conclusion, pentoxifylline proved more effective than the other drugs tested in:

1. improving distal pressure and resting microcirculatory blood flow;

2. increasing postexercise distal flow, ratios, and pressures and enabling faster recuper ation of basal pulse rates;

3. increasing initial claudication distance in the strain test within the test group and achieving a greater absolute subjective claudication distance than that obtained using the other treatments.

Angiology, Vol. 45, No. 7, 647-653 (1994)
DOI: 10.1177/000331979404500708


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