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Angiology
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Flavonoids

A Review of the Pharmacology and Therapeutic Efficacy of Daflon 500 mg in Patients with Chronic Venous Insufficiency and Related Disorders

Jan R. Struckmann, M.D., Ph.D.

Department of Gastroenterological Surgery, Herlev University Hospital, Copenhagen, Denmark, Academic Surgical Unit, Vascular Surgery, Queen Elizabeth the Queen Mother Wing, St. Mary's Hospital Medical School, Imperial College of Science Technology and Medicine, London, England

Andrew N. Nicolaides, M.S., F.R.C.S.

Academic Surgical Unit, Vascular Surgery, Queen Elizabeth the Queen Mother Wing, St. Mary's Hospital Medical School, Imperial College of Science Technology and Medicine, London, England

Daflon 500 mg consists of 450 mg diosmin and 50 mg flavonoid expressed as hesperidin. The authors describe its effects on the microcirculation in chronic venous insufficiency: improvement of venous tone, inhibition of prostaglandin synthesis, protection against free radicals, activation of the complement system, and increased lymphatic drainage. The authors summarize studies of its therapeutic efficacy in reducing venous capaci tance, distensibility, and emptying time; reducing capillary permeability; and increasing capillary resistance.

Angiology, Vol. 45, No. 6, 419-428 (1994)
DOI: 10.1177/000331979404500602
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This article has been cited by other articles:


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 ANGIOLOGYHome page
A. N. Nicolaides
From Symptoms To Leg Edema: Efficacy Of Daflon 500 mg
Angiology, July 1, 2003; 54(1_suppl): S33 - S44.
[Abstract] [PDF]

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 ANGIOLOGYHome page
A. A. Ramelet
Clinical Benefits of Daflon 500 mg in the Most Severe Stages of Chronic Venous Insufficiency
Angiology, August 1, 2001; 52(1_suppl): S49 - S56.
[Abstract] [PDF]


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