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Angiology
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Phosphorus Magnetic Resonance Spectroscopy: A Noninvasive Technique for the Study of Occlusive Arterial Leg Disease and Peripheral Vasodilator Therapy

Denis G. Wahl

Service de Médecine H, Hôpital Central

Jean-Philippe Simon

Service de Médecine H, Hôpital Central

Brigitte Robin

Laboratoire de Biophysique, CHU, Nancy, France

Paul Walker

Laboratoire de Biophysique, CHU, Nancy, France

Pierre Jouanny

Service de Médecine H, Hôpital Central

Jean-Marie Escanye

Laboratoire de Biophysique, CHU, Nancy, France

François Paille

Service de Médecine H, Hôpital Central

Claude Schmidt

Service de Médecine H, Hôpital Central

François Brunotte

Laboratoire de Biophysique, CHU, Nancy, France

Jacques Robert

Laboratoire de Biophysique, CHU, Nancy, France

Jean Schmitt

Service de Médecine H, Hôpital Central

Using 31P nuclear magnetic resonance spectroscopy of the calf muscle, the authors studied patients with peripheral arterial occlusive disease. They studied PCr depletion and intra cellular pH during aerobic exercise in patients and controls. The phosphocreatine (PCr) index {[PCr] / ([PCr] + [Pi])} at rest was correlated with blood flow measured by plethys mography During aerobic exercise a greater decrease in pH was obtained in patients (p < 0.03). They also studied the work necessary to reach a PCr index = 0.5 during ischemic exercise. This workload was lower in patients than in controls: 32.99 ±3.04 J vs 58.89 ±8.55 J, p < 0.05. After vasodilator therapy the workload was improved in patients: 32.99 ±3.04 J vs 38.85 ±3.54 J, p < 0.05. These results suggest that therapy resulted in improved tissue perfusion in patients.

Angiology, Vol. 45, No. 5, 367-376 (1994)
DOI: 10.1177/000331979404500506
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