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Angiology
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Electrical Injury in the Femoral Artery of Rabbits as a Model for Arterial Thrombosis: A Pilot Study

Ran Kornowski

Neufeld Cardiac Research Institute, Sheba Medical Center, and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv Israel

Michael Glikson

Neufeld Cardiac Research Institute, Sheba Medical Center, and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv Israel

Dan Ohad

Neufeld Cardiac Research Institute, Sheba Medical Center, and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv Israel

Nira Varda-Bloom

Neufeld Cardiac Research Institute, Sheba Medical Center, and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv Israel

Alexander Battler

Neufeld Cardiac Research Institute, Sheba Medical Center, and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv Israel

Electrical stimulation was delivered to the femoral artery of 20 rabbits to examine whether endothelial injury results in a consistent formation of arterial thrombosis. The arterial patency was monitored throughout the experiment by flowmeter and was visu alized by femoral angiography in 5/20 cases. The arterial segments remained totally occluded in 7/20 (35%), partially occluded in 9/20 (45%), and patent in 4/20 (20%) rabbits following stimulation with 200 µA anodal current for 180 minutes. The average time of electrical stimulation needed to achieve total occlusion (n = 7) was 110 ±49 minutes. Alternating occlusion and recanalization of the artery (cyclic flow variation) was observed in 12 rabbits, with total occlusion ensuing in 6/12 cases. Intravenous administration of recombinant tissue-type plasminogen activator (20 µg/kg/min for sixty minutes) resulted in femoral reflow and subsequent reocclusion in 2/5 cases. Histopathologic examination disclosed arterial thrombi composed of platelets, fibrin, and red blood cells.

Thus, according to these data this technique was found to induce arterial thrombosis following electrical stimulation of the rabbit femoral artery but was inconsistent regarding the arterial patency.

Angiology, Vol. 45, No. 4, 295-300 (1994)
DOI: 10.1177/000331979404500406
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