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Apolipoproteins C-II and C-III in Peripheral Arterial Disease

"Andrea Cesalpino" Foundation, I Clinica Medica Institute, University of Rome, "La Sapienza," Italy

Stefania Basili

Terapia Medica Institute, University of Rome

Marina Maurelli

"Andrea Cesalpino" Foundation, I Clinica Medica Institute, University of Rome, "La Sapienza," Italy

Paola Andreozzi

Terapia Medica Institute, University of Rome

Anna Colletta

Terapia Medica Institute, University of Rome

Michele Paradiso

Terapia Medica Institute, University of Rome

Corrado Cordova

Terapia Medica Institute, University of Rome

Apolipoprotein (apo) C-II and apo C-III serum concentrations were investi gated in 119 normotriglyceridemic male subjects with peripheral arterial dis ease (PAD) or coronary heart disease (CHD) or without clinical manifestations of atherosclerotic disease. All subjects included in the study had similar blood levels of total cholesterol ( < 400 mg/dL). High-density lipoproteins cholesterol (HDL-C) subfractions and apo A-I serum levels were significantly lower in CHD patients, as were apo A-I/apo B and HDL-cholesterol/total cholesterol ratios. Apo C-II and apo C-III showed similar serum concentrations in all three groups of subjects, but apo C-II/apo C-III ratio was significantly lower in PAD patients as compared with that in CHD patients and control subjects.

This study confirms that PAD may be associated with a particular lipopro tein derangement that primarily involves very low-density lipoprotein catabo lism.

Angiology, Vol. 45, No. 2, 131-136 (1994)
DOI: 10.1177/000331979404500208


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