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Angiology
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Measurements of Human Coronary Vascular Impedance

Anoop Chauhan, M.R.C.P., M.D.

Cardiac Unit, Papworth Hospital, Cambridge, England

Charles D. Potter, B.A.

Cardiac Unit, Papworth Hospital, Cambridge, England

Paul A. Mullins, M.R.C.P.

Cardiac Unit, Papworth Hospital, Cambridge, England

Derek R. Wheeldon, M.I. Biol.

Cardiac Unit, Papworth Hospital, Cambridge, England

Michael C. Petch, M.D.

Cardiac Unit, Papworth Hospital, Cambridge, England

Peter M. Schofield, M.D.

Cardiac Unit, Papworth Hospital, Cambridge, England

The aim of this study was to develop a method of measuring human coronary circulation impedance in a clinical setting. The authors measured coronary flow reserve (CFR) in 27 patients with chest pain and normal coronary arteries. A Judkins-style, 8F Doppler-tipped angiographic catheter was positioned in the left coronary ostium. Resting coronary flow velocity (RFV) and response to a hyperemic 12 mg intracoronary dose of papaverine (PFV) were measured. The signals were recorded by a recorder connected to a micro processor with analogue-to-digital converter and a maths coprocessor. Using this the authors could obtain values for impedance at RFV (IR) and at PFV (IP). The CFR was defined as the ratio: PFV/RFV An impedance index (II) was obtained as the ratio of coronary vascular impedance at peak hyperemia to the impedance at rest. The CFR was 3.2 ±1.2 and the II was 0.33 ±0.11. There was a strong inverse correlation between the CFR and the II (r = -0.9).

The authors conclude that this new approach may allow a further insight into the coronary pathophysiology and may become useful in clinical cardiology, eg, in the assess ment of heart transplant and Syndrome X patients.

Angiology, Vol. 45, No. 12, 991-996 (1994)
DOI: 10.1177/000331979404501201
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