SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
Angiology
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by De Mattia, D.
Right arrow Articles by Schettini, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by De Mattia, D.
Right arrow Articles by Schettini, F.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Association of Congenital Afibrinogenemia and K-Dependent Protein C Deficiency—A Case Report

Domenico De Mattia

Dipartimento di Biomedicina dell'Età Evolutiva-I Clinica Pediatrica, University di Bari

Guido Regina

Cattedra di Chirurgia vascolare, Universita di Bari, Italy

Paola Giordano

Dipartimento di Biomedicina dell'Età Evolutiva-I Clinica Pediatrica, University di Bari

Giovanni Carlo Del Vecchio

Dipartimento di Biomedicina dell'Età Evolutiva-I Clinica Pediatrica, University di Bari

Maria Altomare

Dipartimento di Biomedicina dell'Età Evolutiva-I Clinica Pediatrica, University di Bari

Francesco Schettini

Dipartimento di Biomedicina dell'Età Evolutiva-I Clinica Pediatrica, University di Bari

The authors describe a rare case of congenital afibrinogenemia with concom itant K-dependent protein C deficit that was brought to our observation for ischemic lesions of the foot in association with fibrinogen concentrate infusions.

These lesions can be attributed to the association of various factors: fibrino gen infusion without heparin coverage, microtrauma, and protein C (PC) defi cit. In fact, thromboembolic complications during afibrinogenemia were previously reported usually in association with substitutive therapy, and it is also known that PC deficit predisposes to thrombotic complications.

To the authors' knowledge, the case described by them is the first in which PC deficit is associated with afibrinogenemia. This association cannot be ex plained by a common genetic mechanism because the genes for fibrinogen and for protein C are located on different chromosomes (chromosomes 4 and 2 re spectively) .

Angiology, Vol. 44, No. 9, 745-749 (1993)
DOI: 10.1177/000331979304400913
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?




Advertisement