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Angiology
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*LIDOCAINE
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An Undocumented Effect of Lidocaine Revealed by Computerized Electrocardiography

Ron Leor

Heart Institute, Sheba Medical Center, Tel Hashomer, Tel Aviv University Sackler School of Medicine, Israel

Babeth Rabinowitz

Heart Institute, Sheba Medical Center, Tel Hashomer, Tel Aviv University Sackler School of Medicine, Israel

Hanoch Hod

Heart Institute, Sheba Medical Center, Tel Hashomer, Tel Aviv University Sackler School of Medicine, Israel

Elieser Kaplinsky

Heart Institute, Sheba Medical Center, Tel Hashomer, Tel Aviv University Sackler School of Medicine, Israel

The influence of an intravenous push of lidocaine 1 mg/kg followed by 2 mg/min infusion on total QRS amplitude and R-to-S duration in leads V2-V4 of the electrocardiogram was studied in 11 patients who were hospitalized in the coronary care unit. A computerized system sampled the amplitude and timing of peak R and S waves of 1100 QRS complexes of leads V2-V4, starting two minutes before the first push of lidocaine. Curves of amplitude and R-to-S dura tion versus time were obtained in all patients. QRS amplitude in V2 and V3 increased significantly in 10 of 11 patients (p < 0.005). The mean voltage in crease for all patients was 0.1±0.07 millivolt. The authors also observed a mild prolongation of R-to-S duration (0.8±1.0 millisecond p < 0.02). This new find ing, obtained by a simple computerized system, may possibly have potential future practical clinical application as a feedback parameter for closed-loop control systems for the administration of lidocaine.

Angiology, Vol. 44, No. 7, 517-522 (1993)
DOI: 10.1177/000331979304400702
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