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Angiology
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Nitric Oxide Mediates Vasoactive Effects of Endothelin-3 on Rat Mesenteric Microvascular Beds in Vivo

Iwao Kurose, M.D.

Department of Internal Medicine, School of Medicine, Keio University

Dai Fukumura, M.D.

Department of Internal Medicine, School of Medicine, Keio University

Soichiro Miura, M.D., Ph.D.

Department of Internal Medicine, School of Medicine, Keio University

Eiichi Sekizuka, M.D.

Department of Internal Medicine, School of Medicine, Keio University

Hiroshi Nagata, M.D., Ph.D.

Department of Internal Medicine, School of Medicine, Keio University

Makoto Suematsu, M.D.

Department of Internal Medicine, School of Medicine, Keio University

Masaharu Tsuchiya, M.D., Ph.D.

Department of Internal Medicine, School of Medicine, Keio University

In order to clarify whether the vasoactive effects of endothelin-3 (ET-3) on microvessels are associated with the endothelium-derived relaxing factor (EDRF) in vivo, the authors examined the effects of L-NG-monomethyl arginine (L-NMMA), an analog of L-arginine, on low-dose ET-3 induced hemodynamic changes in the mesenteric microcirculation of male Wistar rats. The intravital observation revealed that ET-3 100 pM induced a remarkable and periodic vasoconstriction in arterioles, and the constriction was sustained for approxi mately fifteen minutes. No remarkable change was observed in the microvessels after the superfusion of 1 pM ET-3. Superfusion of 1 pM ET-3 with 100 µM L-NMMA elicited the vasoconstriction in arterioles, and the arteriolar diameter recovered to the control level within ten minutes in spite of continuing the su perfusion. The vasoconstriction induced by low-dose ET-3 with L-NMMA was suppressed by the additional superfusion of 200 µM L-arginine. The present study suggests that the recovery of arteriolar diameter after the ET-3-induced constriction may be mediated by nitric oxide at least in the early phase.

Angiology, Vol. 44, No. 6, 483-490 (1993)
DOI: 10.1177/000331979304400609
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