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Prevention of Recurrent Deep Venous Thrombosis with Indobufen. A 3-Year Follow-up Study Using Color Duplex Scanning

Microcirculation Laboratory, Cardiovascular Institute, Universita' Abruzzese G.D'Annunzio and The Irvine Cardiovascular Laboratory for Cardiovascular Investigation and Research, St. Mary's Hospital, London, England

B.M. Errichi

Surgical Clinic, Universita' Abruzzese G.D'Annunzio, Chieti, Italy

P. De Simone

Microcirculation Laboratory, Cardiovascular Institute, Universita' Abruzzese G.D'Annunzio and The Irvine Cardiovascular Laboratory for Cardiovascular Investigation and Research, St. Mary's Hospital, London, England

After an episode of deep venous thrombosis (DVT) 123 patients were ran domized into two groups: one was prophylactically treated with indobufen (60 patients), an oral antiplatelet agent, and one had no treatment (63) and acted as a control group. They were followed up for three years and scanned with color duplex scanning (CDS) every three months and any time that signs and symp toms suggested a new episode.

In patients receiving indobufen the incidence of thrombosis was 5% in three years while it was significantly higher (46%) in the control group. Also 62% of the new episodes in the control group were asymptomatic (33.3% in the treated group).

Results suggest that recurrent DVT is common, often asymptomatic, and confused with sequelae of the initial episode. The prophylaxis with indobufen is an effective measure in preventing recurrent thrombosis and avoiding the pro gressive deterioration of the deep venous system observed after deep venous thrombosis.

Angiology, Vol. 44, No. 4, 328-331 (1993)
DOI: 10.1177/000331979304400410


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