This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Wagner, D.R. Articles by Middeke, M. Search for Related Content PubMed PubMed Citation Articles by Wagner, D.R. Articles by Middeke, M. Social Bookmarking                         What's this?

Clinical Case Reports

Erythromelalgia Unmasked During Norephedrine Therapy: A Case Report

Medical Policlinic of the University of Munich, Germany

F. Spengel

Medical Policlinic of the University of Munich, Germany

M. Middeke

Medical Policlinic of the University of Munich, Germany

A thirty-eight-year-old woman presented with typical signs of erythromelal gia : burning, redness, and warm congestion of the extremities. These symptoms occurred after cessation of obesity drug therapy with norephedrine (250 mg/ day) continuously over six years. The condition was refractory to treatment with acetylsalicylic acid. It is suggested that erythromelalgia in this case was unmasked by the vasoactive properties of norephedrine. Continuous drug ther apy with norephedrine may have led to adaptive adrenergic subsensitivity of vascular smooth muscles. The pathomechanism of primary erythromelalgia is still unknown. Their observations suggest that an enhanced vasodilatation due to an abnormal adrenergic sensitivity may play an important role in the patho genesis of primary erythromelalgia.

Angiology, Vol. 44, No. 3, 244-247 (1993)
DOI: 10.1177/000331979304400310


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?