This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Agishi, T. Articles by Nomura, M. Search for Related Content PubMed PubMed Citation Articles by Agishi, T. Articles by Nomura, M. Social Bookmarking                         What's this?

Treatment of Arteriosclerotic Obstruction by LDL Adsorption

Kidney Center, Tokyo Women's Medical College

Shinji Naganuma

Kidney Center, Tokyo Women's Medical College

Satoshi Nakasato

Kidney Center, Tokyo Women's Medical College

Kumiko Kitajima

Kidney Center, Tokyo Women's Medical College

Kazuo Ota

Kidney Center, Tokyo Women's Medical College

Kimio Ban

Kanekafuchi Chemical Industries, Inc., Tokyo, Japan

Minoru Nomura

Kanekafuchi Chemical Industries, Inc., Tokyo, Japan

According to the authors' clinical analysis, about half of the patients who suffer from arteriosclerotic obstruction (ASO) in the lower extremity(-ies) with clinical manifestation are dyslipidemic (total cholesterol 220 mg/dL or LDL cholesterol 140 mg/dL). As suggested by clinical success in regression of ASO in the coronary arteries as a result of aggressive removal of LDL, LDL adsorp tion utilizing an extracorporeal circulation technique with a dextran sulfate/cel lulose adsorbent column was applied in 33 patients (22 men and 11 women) with ASO. Clinical results obtained after a series of 10 LDL adsorption procedures as a standard showed encouraging success. Improvement in subjective symp toms was achieved as follows: 88.5% for cold lower extremity, 87.1% for inter mittent claudication, 53.8% for leg/toe pain at rest, and 60% for disappearance/ size diminution of ulcer/necrosis. Improvements in objective examination find ings supported subjective ones: 85.7% by plethysmography, 81% by thermogra phy and 70% by ankle pressure index. No serious complications or untoward ef fects were observed during or after the adsorption procedures. In conclusion, LDL adsorption appears to be a useful and safe tool in treatment of ASO pa tients with dyslipidemia.

Angiology, Vol. 44, No. 3, 222-227 (1993)
DOI: 10.1177/000331979304400308


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?