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Concentric Left Ventricular Hypertrophy in Patients with Takayasu Arteritis

Third Department of Internal Medicine, Tokyo Medical and Dental University, School of Medicine, Tokyo, Japan

Toshiyuki Oniki

Third Department of Internal Medicine, Tokyo Medical and Dental University, School of Medicine, Tokyo, Japan

Eiji Kaneko

Third Department of Internal Medicine, Tokyo Medical and Dental University, School of Medicine, Tokyo, Japan

Akihiro Hata

Third Department of Internal Medicine, Tokyo Medical and Dental University, School of Medicine, Tokyo, Japan

Akihiko Matsumura

Third Department of Internal Medicine, Tokyo Medical and Dental University, School of Medicine, Tokyo, Japan

Takahiro Kobayashi

Third Department of Internal Medicine, Tokyo Medical and Dental University, School of Medicine, Tokyo, Japan

Fujio Numano

Third Department of Internal Medicine, Tokyo Medical and Dental University, School of Medicine, Tokyo, Japan

Although aortic regurgitation (AR) in patients with Takayasu arteritis (TA) is believed to be caused by dilatation of the aortic ring or thickening of the aortic cusps, the pattern of left ventricular hypertrophy (LVH) in these patients has not been described. To clarify the geometry of the LV in patients with TA that had been documented both echocardiographically and hemodynamically, the authors evaluated 22 patients with TA and severe AR (group 1), 10 with TA and systemic hypertension (group 2), and 17 with isolated severe AR of other etiolo gies (group 3). M-mode echocardiography showed that LV dimensions were smaller in groups 1 and 2 than in group 3 and that wall thickness was greater in group 1 than in group 3. The concentric hypertrophic ratio (CHR = wall thick ness/LV end-diastolic dimension + wall thickness) was larger than group 1 (p < 0.001) and group 2 (p < 0.01) than in group 3. CHR was similar in groups 1 and 2. Systolic blood pressure was significantly increased in group 2 and showed a tendency to increase in group 1 as compared with group 3. The results confirmed the presence of concentric LVH related to a pressure overload in patients with TA, even when TA was complicated by severe AR.

Angiology, Vol. 44, No. 11, 883-888 (1993)
DOI: 10.1177/000331979304401106


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