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Coronary Heart Disease, Echo-Doppler Evidence of Peripheral Arterial Disease and Polymorphism of Apolipoprotein B Gene and Apo AI/CIII Cluster

Institute of Internal Medicine and Metabolic Diseases, 2nd Medical School University of Naples

Paolo Rubba, M.D.

Institute of Internal Medicine and Metabolic Diseases, 2nd Medical School University of Naples

Antonella Monticelli, M.D.

Dipartimento di Biologia e Patologia Cellulare e Molecolare Universitá degli Studi di Napoli, CEOS CNR. Settore di Genetica Molecolare Policlinico della Facoltá di Medicina e Chirurgia, Naples, Italy

Sergio Cocozza, M.D.

Dipartimento di Biologia e Patologia Cellulare e Molecolare Universitá degli Studi di Napoli, CEOS CNR. Settore di Genetica Molecolare Policlinico della Facoltá di Medicina e Chirurgia, Naples, Italy

The possible associations between coronary heart disease (CHD) and peripheral arterial disease (PAD), detected by echo-Doppler analysis, with restriction fragment length polymorphism (RFLP) of apo AI/CIII cluster and apo B gene were investigated in a group of men with premature CHD (n = 39) and in a control group of men without evidence of CHD (n=40). The genetic analysis of SstI RFLP of apo AI/CIII cluster showed a significantly higher frequency of the rare SstI allele (S2) in CHD patients (0.16) as compared with controls (0.06). No significant differences were found in the frequencies of XbaI RFLP for the apo B gene between CHD patients and controls. Moreover, patients with PAD showed no significant differences in the frequencies of XbaI RFLP for the apo B gene and of SstI RFLP for the apo AI/CIII cluster as compared with patients without evidence of peripheral arterial disease detected by echo-Doppler analysis.

Angiology, Vol. 44, No. 10, 785-790 (1993)
DOI: 10.1177/000331979304401004


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