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Angiology
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Double-Blind Comparison of Captopril with Nifedipine in Hypertension Complicated by Intermittent Claudication

David H. Roberts, M.D.

Department of Pharmacology and Therapeutics, University of Liverpool

Yvonne Tsao

Department of Pharmacology and Therapeutics, University of Liverpool

Keith Linge

Royal Liverpool Hospital, Liverpool, England

Gerard A. McLoughlin, F.R.C.S.

Royal Liverpool Hospital, Liverpool, England

Alasdair Breckenridge, M.D.

Department of Pharmacology and Therapeutics, University of Liverpool

In a double-blind, crossover trial 12 patients with hypertension and peripheral arterial disease were randomized to three months' treatment with captopril 25-50 mg twice daily or nifedipine SR 20-40 mg twice daily. While both treatments were equally effective at lowering blood pressure, postexercise calf blood flow availability was greater during treatment with captopril (P < 0.04). This was not reflected in walking capacity assessed by treadmill exercise. The results sug gest that both captopril and nifedipine are appropriate antihypertensive agents in patients with peripheral arterial disease.

Angiology, Vol. 43, No. 9, 748-756 (1992)
DOI: 10.1177/000331979204300905
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