This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Nagano, H. Articles by Asano, M. Search for Related Content PubMed PubMed Citation Articles by Nagano, H. Articles by Asano, M. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB INDOMETHACIN Social Bookmarking                         What's this?

Cerebral Microcirculatory Changes After Cerebral Embolization Induced by Glass Bead Injection in Rabbits

Kumamoto Research Laboratory, Sanwa Kagaku Kenkyusho Co., Ltd., Kumamoto

Tsunemasa Suzuki

Kumamoto Research Laboratory, Sanwa Kagaku Kenkyusho Co., Ltd., Kumamoto

Motohide Hayashi

Kumamoto Research Laboratory, Sanwa Kagaku Kenkyusho Co., Ltd., Kumamoto

Makishige Asano

Division of Health Science, School of Allied Health Sciences, Faculty of Medicine, Tokyo Medical and Dental University, Tokyo, Japan

The authors investigated microcirculatory changes in cerebral embolization induced by an injection of glass beads (mesh size 20/400, 15 mg/body) using intravital microscopy and reflectance spectrophotometry in normal rabbits. Cerebral embolization with the glass bead injection reduced the inner diameter of cerebral arterioles, the index of cerebral hemoglobin concentration (IHb), and the index of oxygen saturation (ISO₂). Moreover, platelet aggregation rates and plasma levels of thromboxane B₂ (TXB₂) and 6-keto-prostaglandin F₁ (6-keto-PGF₁) appreciably increased. During observation of the pial vasculature, "white bodies" became visible at the entrance of arteriolar branchings two to three minutes after the glass bead injection. After indomethacin administration (3 mg/kg, IV), they could not observe white bodies, and platelet aggregation rates were significantly reduced. The plasma levels of TXB₂ and 6-keto-PGF₁ were also significantly reduced. These findings suggest that glass beads do injury to the microvascular endothelial cells leading to development of white bodies, ie, "flying thrombi." Therefore, the cerebral microvascular embolization induced by the glass bead injection appears to be an experimental model for evaluating efficacy of remedies for the cerebral microcirculatory disorders.

Angiology, Vol. 43, No. 8, 678-684 (1992)
DOI: 10.1177/000331979204300808


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?