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Angiology
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Favorable Clinical Effects of Iloprost Infusion in 4 Uremic Patients with Critical Limb Ischemia

Pier Luigi Bedani

Division of Nephrology, S. Anna Hospital

Leonella Perini

Division of Nephrology, S. Anna Hospital

Roberto Farinelli

Division of Nephrology, S. Anna Hospital

Fabio Fabbian

Division of Nephrology, S. Anna Hospital

Orazio Fiocchi

Division of Nephrology, S. Anna Hospital

Severino Guerra

Institute of Medical Pathology, University of Ferrara, Italy

Antonietta Vanini

Division of Medicine, S. Anna Hospital, Ferrara

Paolo Gilli

Division of Nephrology, S. Anna Hospital

Four uremic patients with advanced peripheral arterial occlusive disease (PAOD) of lower limbs causing rest pain and ischemic-necrotic lesions were treated with a four-hour intravenous infusion of Iloprost at doses of 0.75-2.5 ng/kg/min for twenty-eight days. After a week of the therapy all patients experi enced disappearance of rest pain and prolonged walking distance. At the end of the trial a diabetic patient showed a complete regression of the necrotic areas of two toes while the other patients still showed ischemic-necrotic foot lesions that were well demarcated.

Iloprost therapy can be effective in uremic patients with severe PAOD.

Angiology, Vol. 43, No. 5, 408-411 (1992)
DOI: 10.1177/000331979204300506
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