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Angiology
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The Effect of Enalapril Maleate on Cerebral Blood Flow in Chronic Cerebral Infarction

Shotai Kobayashi

From the 3rd Department of Internal Medicine, Shimane Medical University

Shuhei Yamaguchi

From the 3rd Department of Internal Medicine, Shimane Medical University

Kazunori Okada

From the 3rd Department of Internal Medicine, Shimane Medical University

Nobuo Suyama

From the 3rd Department of Internal Medicine, Shimane Medical University

Kazunori Bokura

From the 3rd Department of Internal Medicine, Shimane Medical University

Mituyoshi Murao

Shimane Institute of Health Science, Izumo, Japan

The influence of long-term oral administration of enalapril maleate (an an giotensin II-converting enzyme inhibitor) on regional cerebral blood flow (rCBF) was studied in 10 patients with chronic cerebral infarction. The rCBF was meas ured by a 133Xe inhalation method before and after a mean of sixty-five days' administration of 5 mg of enalapril.

Results: Mean arterial blood pressure (MABP) was mildly decreased in 6 pa tients, but the average change in MABP was not significant (Endtidal partial pressure of carbon dioxide (PeCO2) was not changed significantly. The mean rCBF was increased by 8% after administration of enalapril (0.05 < p<0.1) There was no significant correlation between percent change in MABP and the percent change in rCBF. These results indicate that enalapril has not only antihyperten sive action but also a beneficial effect on the cerebral circulation in patients with chronic cerebral infarction.

Angiology, Vol. 43, No. 5, 378-388 (1992)
DOI: 10.1177/000331979204300502
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This article has been cited by other articles:


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 ANGIOLOGYHome page
H. Kamishirado, T. Inoue, T. Fujito, M. Kase, M. Shimizu, Y. Sakai, K. Takayanagi, S. Morooka, S. Natsui, and H. Kamishirado
Effect of Enalapril Maleate on Cerebral Blood Flow in Patients with Chronic Heart Failure
Angiology, August 1, 1997; 48(8): 707 - 713.
[Abstract] [PDF]


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