This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Kato, T. Articles by Fujinami, T. Search for Related Content PubMed PubMed Citation Articles by Kato, T. Articles by Fujinami, T. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Medline Plus Health Information High Blood Pressure Social Bookmarking                         What's this?

Effects of Prostacyclin Infusion on Blood Pressure and Plasma Renin Activity in Patients with Essential Hypertension

Department of Anesthesiology, Toyokawa City Hospital, Aichi

Syunki Yoneda, M.D., F.I.C.A.

Third Department of Internal Medicine, Nagoya City University Medical School, Aichi, Japan

Masaaki Koketsu, M.D., F.I.C.A.

Third Department of Internal Medicine, Nagoya City University Medical School, Aichi, Japan

Takao Fujinami, M.D., F.I.C.A.

Third Department of Internal Medicine, Nagoya City University Medical School, Aichi, Japan

The effects of prostacyclin infusion (6.7 ± 2.7 ng/kg/min, 3 to 10 ng/kg/min) on blood pressure, plasma renin activity (PRA), and 6-keto-prostaglandin F₁ (6-keto-PGF₁) were studied in 7 patients with essential hypertension (4 men and 3 women) with a mean age of fifty-eight ± eleven years (forty-six to seventy- four years). The baseline value of 6-keto-PGF₁ for patients with essential hypertension was not lower than in healthy subjects. Blood pressure immediate ly dropped following prostacyclin infusion. Systolic blood pressure returned to the baseline value after prostacyclin infusion was discontinued. However, di astolic blood pressure and mean arterial blood pressure were still significantly decreased thirty minutes after termination of infusion. Heart rate did not change during prostacyclin infusion but decreased significantly when infusion was ter minated. PRA was not significantly affected by prostacyclin infusion. The 6-keto- PGF ₁ level was about 8 times higher than the baseline value thirty minutes af ter initiation of prostacyclin infusion and approximately twice as high as the base line value thirty minutes after termination of infusion. The decrease in mean arterial blood pressure coincided with the increase in 6-keto-PGF₁. There was no correlation between mean arterial blood pressure and PRA, nor between PRA and 6-keto-PGF₁.

These results demonstrate that production of prostacyclin is not reduced in patients with essential hypertension, and heart rate and PRA are not changed by prostacyclin infusion, although prostacyclin decreases blood pressure.

Angiology, Vol. 43, No. 2, 110-120 (1992)
DOI: 10.1177/000331979204300204


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?