This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Cogo, A. Articles by Ruol, A. Search for Related Content PubMed PubMed Citation Articles by Cogo, A. Articles by Ruol, A. Social Bookmarking                         What's this?

Failure of Thrombin-Antithrombin III Complexes in the Diagnosis of Deep Vein Thrombosis

Clinica Medica , University of Padua, Padua, Italy

Anthonie Lensing

Centre for Thrombosis, Haemostasis and Atherosclerosis Research, Academic Medical Centre, Amsterdam, the Netherlands

Paolo Prandoni

Clinica Medica , University of Padua, Padua, Italy

Giuseppe Canova

Clinica Medica , University of Padua, Padua, Italy

Renzo De Toni

Clinica Medica , University of Padua, Padua, Italy

Stefano Cuppini

Clinica Medica , University of Padua, Padua, Italy

Arturo Ruol

Clinica Medica , University of Padua, Padua, Italy

Plasma thrombin-antithrombin III (T-AT) complexes are reputed to be an indirect manifestation of thrombin generation, and a role for their determina tion in the diagnosis of deep vein thrombosis (DVT) has been advocated. In order to evaluate the accuracy of T-AT complexes assay for DVT diagnosis, in 166 consecutive outpatients with clinical suspicion of the disease, plasma con centration of T-AT complexes was measured immediately before venography by means of an enzyme-linked immunosorbent assay kit. The result of the T-AT complexes assay was elevated in 29 of the 48 patients with DVT (sensitivity, 60%). The T-AT complexes levels were within the normal range in 104 of the 118 patients with normal venograms (specificity, 88%). The positive and the nega tive predictive value were 67% and 85%, respectively. The authors conclude that the T-AT complexes assay is of little value for the diagnosis of DVT in outpatients.

Angiology, Vol. 43, No. 12, 975-979 (1992)
DOI: 10.1177/000331979204301203


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				R. Bona, A. Hickey, L. Greenwald, E. Sullivan, P. Livadiotis, O. Johnson, A. Kulak, S. Wajcs, and K. Vose Low Risk of Subsequent Deep-Venous Thrombosis in Patients with a Negative Venous Duplex Scan Clinical and Applied Thrombosis/Hemostasis, January 1, 1996; 2(1): 30 - 34. [Abstract] [PDF]