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Angiology
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Influence of Deproteinized Hemodialysate on Rest Pain and Walking Distance in the Presence of Peripheral Chronic Arterial Occlusive Disease

Bernhard Angelkort, M.D., F.A.C.A.

Department of Central Medicine, Municipal Hospital, Dortmund

Kurt-Ulrich Rühlmann, M.D.

Centre for Angiology, Aachen

Rainer de la Haye, Psy

Centre for Angiology, Aachen

Günter Kuntz, M.D.

Hormon-Chemie München GmbH, Germany

In a controlled and randomized single-blind study (blind observer) the clinical efficacy of intra-arterial therapy with a metabolically active deproteinized dialysate from calf blood has been tested against a vasodilating and hemorheologically active reference substance (bencyclan). Over a period of four weeks 28 patients each received 20 intra-arterial infusions of the deproteinized hemodialysate 20% for infusion. The reference group with 30 patients was treated with 250 mg bencyclan in 250 mL saline 0.9%. As for the target criteria, rest pain and consumption of analgesics, the hemodialysate treatment proved superior to the therapy with the reference substance. Both preparations induced to a small extent pain-free walking distances: hemodialysate group, 29.2 ±14.6 m; reference group, 25.8±18.7 m (group difference not significant).

Angiology, Vol. 43, No. 1, 47-58 (1992)
DOI: 10.1177/000331979204300106
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