SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
Angiology
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Shigematsu, S.
Right arrow Articles by Shimizu, Z.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Shigematsu, S.
Right arrow Articles by Shimizu, Z.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Differential Effects of Nifedipine on Plasma Atrial Natriuretic Peptide in Normal Subjects and Hypertensive Patients

Satoshi Shigematsu, M.D.

Department of Gerontology, Endocrinology, and Metabolism, School of Medicine, Shinshu University, Matsumoto-shi

Takashi Yamada, M.D., Ph.D., F.I.C.A.

Department of Gerontology, Endocrinology, and Metabolism, School of Medicine, Shinshu University, Matsumoto-shi

Toru Aizawa, M.D., Ph.D.

Department of Gerontology, Endocrinology, and Metabolism, School of Medicine, Shinshu University, Matsumoto-shi

Nobuyuki Takasu, M.D., Ph.D.

Department of Gerontology, Endocrinology, and Metabolism, School of Medicine, Shinshu University, Matsumoto-shi

Zenji Shimizu, M.D., Ph.D.

Department of Medicine, Hokushin General Hospital, Nakano-shi, Nagano-ken, Japan

The physiology of atrial naturiuretic peptide (ANP) secretion was studied in normotensive subjects and hypertensive patients both young and old. Basal plasma ANP concentration was least in young normotensives, intermediate in old normotensives and young hypertensives, and highest in old hypertensives. Nifedipine, a known stimulator of ANP secretion, acutely increased plasma ANP in young and old normotensive subjects but not in young hypertensive patients and half of the old hypertensive patients. Increase in serum ANP level in response to nifedipine did not augment its hypotensive effect. However, the increase of aldosterone in response to nifedipine-induced rise in plasma renin activity (PRA) seemed to be suppressed by elevated ANP.

Angiology, Vol. 43, No. 1, 40-46 (1992)
DOI: 10.1177/000331979204300105
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?




Advertisement