SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
Angiology
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Saito, I.
Right arrow Articles by Sekihara, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Saito, I.
Right arrow Articles by Sekihara, T.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Effect of L-dopa in Young Patients with Hypertension

Ikuo Saito

Center of Medicine, Keio University

Hiroshi Kawabe

Center of Medicine, Keio University

Chika Hasegawa

Department of Internal Medicine, Keio University

Yasushi Iwaida

Department of Internal Medicine, Keio University

Hiroshi Yamakawa

Department of Internal Medicine, Keio University

Takao Saruta

Department of Internal Medicine, Keio University

Eiko Takeshita

Laboratory of Medicine, Keio University, Tokyo, Japan

Shiro Nagano

Center of Medicine, Keio University

Toshio Sekihara

Center of Medicine, Keio University

The effects of L-dopa on blood pressure, heart rate, plasma renin activity, norepinephrine, epinephrine and prolactin were studied in a randomized single-blind trial in 36 patients with essential hypertension. In response to L-dopa, 250 mg administered orally, the blood pressure decreased significantly as compared with the results of placebo treatment. The heart rate and plasma norepinephrine and epinephrine were unchanged. The plasma renin activity and prolactin decreased as a result of L-dopa administration. The administration of a peripheral DA2 dopamine receptor blocker, domperidone (20 mg, orally) prevented the L-dopa-induced reduction in plasma prolactin but failed to block the fall in blood pressure and plasma renin activity. These results suggest that the blood pressure-lowering effect of L-dopa may be mediated through multiple sites involving D1 dopamine receptors, the central nervous system, and the renin-angiotensin system.

Angiology, Vol. 42, No. 9, 691-695 (1991)
DOI: 10.1177/000331979104200902
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 J. Neurol. Neurosurg. PsychiatryHome page
J. Ludwig, P. Remien, C. Guballa, A. Binder, S. Binder, J. Schattschneider, J. Herzog, J. Volkmann, G. Deuschl, G. Wasner, et al.
Effects of subthalamic nucleus stimulation and levodopa on the autonomic nervous system in Parkinson's disease
J. Neurol. Neurosurg. Psychiatry, July 1, 2007; 78(7): 742 - 745.
[Abstract] [Full Text] [PDF]

Home page
 ANGIOLOGYHome page
H. Kawabe, I. Saito, C. Hasegawa, S. Nagano, and T. Saruta
Circulatory and Plasma Catecholamine Responses to Mental Stress in Young Subjects with two Different Types of Hypertension
Angiology, June 1, 1994; 45(6): 435 - 441.
[Abstract] [PDF]


Advertisement