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Angiology
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Serum Lipoprotein (a) Levels in Men with Peripheral Vascular Disease

Xavier Nogués

Department of Medicine, Hospital de la Esperanza

Mariano Seni

Department of Medicine, Hospital del Mar, Instituto Municipal de Investigación Médica, Universidad Autónoma de Barcelona, Barcelona, Spain

Juan Pedro-Botet

Department of Medicine, Hospital del Mar, Instituto Municipal de Investigación Médica, Universidad Autónoma de Barcelona, Barcelona, Spain

Juan Rubiés-Prat

Department of Medicine, Hospital del Mar, Instituto Municipal de Investigación Médica, Universidad Autónoma de Barcelona, Barcelona, Spain

Francesc Vidal-Barraquer

Department of Vascular Surgery, Hospital de la Esperanza

The authors quantified serum lipoprotein (a) (Lp) (a) by enzymoimmunoanalysis in 86 outpatient men suffering peripheral vascular disease (PVD) and in 53 age-matched healthy men. They further measured serum cholesterol, serum triglycerides, low density lipoproteins-cholesterol, high density lipoproteins (HDL)-cholesterol and serum apolipoprotein B. Serum triglycerides were significantly increased in patients with PVD versus controls (148 ± 8 and 114 ± 7 mg/dL, mean ± SEM). HDL-cholesterol levels were significantly lower in patients versus controls (36 ± 1 and 43 ± 2 mg/dL, respectively). Serum Lp(a) levels in patients with PVD were 20 ± 2 mg/dL, whereas in controls they were 16 ± 3 (p: NS). Serum Lp(a) concentrations were identical in smoker and nonsmoker patients. There was no correlation between Lp(a) concentration and the other lipid parameters. Conversely, as occurs in coronary heart disease and in cerebrovascular disease, Lp(a) does not seem to be a marker for PVD, although a trend toward a higher mean levels was found.

Angiology, Vol. 42, No. 8, 659-664 (1991)
DOI: 10.1177/000331979104200809
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