This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Valentine, J. L. Articles by Phillips, S. W. Search for Related Content PubMed PubMed Citation Articles by Valentine, J. L. Articles by Phillips, S. W. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB COCAINE Social Bookmarking                         What's this?

Effects of Cocaine on Canines' Coronary Arteries

Departments of Pharmacology, Radiology, and Internal Medicine, Oral Roberts University School of Medicine, Tulsa, Oklahoma

William S. Yamanashi

Departments of Pharmacology, Radiology, and Internal Medicine, Oral Roberts University School of Medicine, Tulsa, Oklahoma

David Leak

Departments of Pharmacology, Radiology, and Internal Medicine, Oral Roberts University School of Medicine, Tulsa, Oklahoma

Seppo Saksanen

Departments of Pharmacology, Radiology, and Internal Medicine, Oral Roberts University School of Medicine, Tulsa, Oklahoma

Benny D. Wagner

Departments of Pharmacology, Radiology, and Internal Medicine, Oral Roberts University School of Medicine, Tulsa, Oklahoma

Steven W. Phillips

Departments of Pharmacology, Radiology, and Internal Medicine, Oral Roberts University School of Medicine, Tulsa, Oklahoma

Nine canines were anesthetized with pentobarbital and studied by both selective and semiselective coronary artery angiography following intravenous bolus doses of 1,3,5,8, or 10 mg/kg of cocaine. Catheterization was accomplished with a 5 Fr catheter over a 0.035 inch guidewire under fluoroscopic control, and angio grams were obtained by injection of a diatrizoate solution. Digital subtraction angiography (DSA) was performed prior to cocaine administration and at minutes 0.5, 1,1.5, 3, 5, and, in some cases, minutes 10 and 15 after cocaine administra tion. The 1 and 3 mg/kg doses of cocaine had no effect on the coronary arter ies. The 5 mg/kg dose significantly dilated the coronary arteries. The 8 mg/kg dose produced significant dilation at 30 seconds after cocaine but nonsignifi cant dilation of the coronary arteries at all other times. The 10 mg/kg dose produced significant dilation at 30 seconds, nonsignificant dilation at 60 seconds followed by significant constriction at 90 seconds after cocaine, which led to immediate death in most animals. The coronary dilation and constriction produced by 10 mg/kg of cocaine could be prevented by either preadministra tion or postadministration of naloxone, but this did not prevent subsequent death.

Angiology, Vol. 42, No. 7, 568-575 (1991)
DOI: 10.1177/000331979104200708


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?