This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Mannarino, E. Articles by Ciuffetti, G. Search for Related Content PubMed PubMed Citation Articles by Mannarino, E. Articles by Ciuffetti, G. Social Bookmarking                         What's this?

Physical Training and Antiplatelet Treatment in Stage II Peripheral Arterial Occlusive Disease: Alone or Combined?

Angiology Section, 2nd Dept. Internal Medicine, University of Perugia, Perugia, Italy

Leonella Pasqualini

Angiology Section, 2nd Dept. Internal Medicine, University of Perugia, Perugia, Italy

Salvatore Innocente

Angiology Section, 2nd Dept. Internal Medicine, University of Perugia, Perugia, Italy

Vito Scricciolo

Angiology Section, 2nd Dept. Internal Medicine, University of Perugia, Perugia, Italy

Antonio Rignanese

Angiology Section, 2nd Dept. Internal Medicine, University of Perugia, Perugia, Italy

Giovanni Ciuffetti

Angiology Section, 2nd Dept. Internal Medicine, University of Perugia, Perugia, Italy

The efficacy of physical training alone or combined with antiplatelet thera py (dipyridamole and aspirin) was studied in 30 patients with stage II peripheral arterial occlusive disease (PAOD).

Patients were randomly allocated to one of the following groups: Group A— dipyridamole 75 mg three times daily and aspirin 330 mg once daily: Group B— physical exercise; Group C—physical exercise and dipyridamole 75 mg three time daily and aspirin 330 mg once daily.

After six months' treatment the pain-free walking time (PFWT) and the max imum walking time (MWT) improved significantly (p < 0.05) in all three groups. In group A the PFWT lengthened by 35% (from 101.00 ± 34.56 to 137.32 ± 40.50 s) and the MWT by 38% (from 150.34 ± 55.60 to 207.26 ± 60.67 s); in group B the PFWT lengthened by 90% (from 90.65 ± 40.54 to 171.45 ± 55.60 s) and the MWT by 86% (from 145.39 ± 60.50 to 270.63 ± 63.61 s). When physical exer cise was associated with drugs as in group C, the PFWT lengthened by 120% (from 89.51 ± 43.89 to 196.72 ±51.73 s) and the MWT by 105% (from 160.43 ± 59.84 to 329.05 ± 63.96 s). No significant variations were observed at any stage of the study in the ankle/arm pressure ratio at rest and after standard treadmill exercise, in the plethysmographic rest and peak flows, or in the trans cutaneous oxygen pressure in basal conditions and in its half recovery time after an induced ischemia.

The results confirm the benefits of regular exercise in stage II PAOD pa tients but suggest they may be enhanced by antiplatelet therapy.

Angiology, Vol. 42, No. 7, 513-521 (1991)
DOI: 10.1177/000331979104200701


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				C. J. Womack and A. W. Gardner The Effect of Indirect Calorimetry Measurement on Claudication Pain in Patients with Peripheral Arterial Occlusive Disease Angiology, December 1, 1998; 49(12): 985 - 990. [Abstract] [PDF]