SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
Angiology
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Demiroglu, C.
Right arrow Articles by Büyükdevrim, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Demiroglu, C.
Right arrow Articles by Büyükdevrim, S.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Suppression of Atherogenesis by n-3 Fatty Acids in the Cholesterol-Fed Rabbit

Cem'i Demiroglu

Institute of Cardiology, University of Istanbul

Ayse Özder

Institute of Cardiology, University of Istanbul

Tuncay Altug

Experimental Medical Research and Application Center, University of Istanbul

Billur Orbay

Institute of Cardiology, University of Istanbul

Süheda Satar-Yíldírím

Institute of Cardiology, University of Istanbul

Ayhan Bilir

Department of Histology and Embryology, Istanbul Medical Faculty, University of Istanbul, Istanbul, Turkey

Günnur Deniz

Experimental Medical Research and Application Center, University of Istanbul

Türkan Erbengi

Department of Histology and Embryology, Istanbul Medical Faculty, University of Istanbul, Istanbul, Turkey

Sevim Büyükdevrim

Experimental Medical Research and Application Center, University of Istanbul

The effects of n-3 fatty-acid supplementation on serum lipids, platelet aggre gation, and the development of atherosclerotic lesions were studied in the choles terol-fed rabbit. Serum total cholesterol and LDL cholesterol values were significantly reduced in comparison with those of the nonsupplemented choles terol-fed group (p<0.005, p<0.0025, respectively), though still higher than those of the control group (p<0.0025, p<0.0125 respectively). Platelet aggregation was reduced below that of the cholesterol-fed and the control levels (p<0.0005, p<0.0025, respectively). The endothelial injury encountered in cholesterol-fed rabbits was inhibited in the supplemented group. It is concluded that n-3 fatty acids suppress atherogenesis in this animal model by interfering with platelet aggregation and lipid metabolism.

Angiology, Vol. 42, No. 4, 323-330 (1991)
DOI: 10.1177/000331979104200410
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?




Advertisement