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Angiology
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Age-Related Changes in Red Blood Cell Lipids

Domenico Prisco

Clinica Medica I, University of Florence, Florence, Italy

Pier Giorgio Rogasi

Clinica Medica I, University of Florence, Florence, Italy

Rita Paniccia

Clinica Medica I, University of Florence, Florence, Italy

Rosanna Abbate

Clinica Medica I, University of Florence, Florence, Italy

Gian Franco Gensini

Clinica Medica I, University of Florence, Florence, Italy

Red blood cell (RBC) lipid composition was investigated in 81 healthy subjects aged twenty to sixty-nine years, having similar dietary habits, and living in the same geographic area in order to search for changes referable to aging. A significant increase in RBC cholesterol and total phospholipid content with aging was found (p<0.001), whereas no differences were observed in cholesterol/phos pholipid molar ratio. Significant increases in palmitic acid 16:0 esterified in phosphatidylcholine and in stearic acid 18:0 esterified in phosphatidylethanolam ine (p<0.001) were observed with aging. Moreover, a decrease in 18:2 n6 was observed in all three phosphoglyceride fractions investigated (p<0.001). These results suggest that modifications in RBC lipid composition occur with aging, possibly causing a reduction of membrane fluidity.

Angiology, Vol. 42, No. 4, 316-322 (1991)
DOI: 10.1177/000331979104200409
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