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Angiology
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EPA in the Prevention of Restenosis Post PTCA

Mark Howard Bowles

Wichita Institute for Clinical Research, Wichita, Kansas

Demo Klonis

Wichita Institute for Clinical Research, Wichita, Kansas

Thomas G. Plavac

Wichita Institute for Clinical Research, Wichita, Kansas

Brenda Gonzales

Wichita Institute for Clinical Research, Wichita, Kansas

Dan A. Francisco

Wichita Institute for Clinical Research, Wichita, Kansas

Roger W. Roberts

Wichita Institute for Clinical Research, Wichita, Kansas

Gregory R. Boxberger

Wichita Institute for Clinical Research, Wichita, Kansas

Larry R. Poliner

Wichita Institute for Clinical Research, Wichita, Kansas

Joseph P. Galichia

Wichita Institute for Clinical Research, Wichita, Kansas

The effect of fish oil on restenosis was evaluated in patients undergoing coronary balloon angioplasty. In addition to routine pharmacotherapy, subjects were given 2.8 g of eicosapentanoic acid (EPA) daily. Treatment was started within twenty-four hours after successful percutaneous transluminal coronary angioplasty (PTCA). After six months of therapy, participants were subjected to coronary arteriography, exercise scintigraphy, exercise electrocardiography, or clinical evaluation.

Follow-up evaluation involved 97 coronary lesions in 85 patients. Partial or significant restenosis occurred in 36.5% of patients and 33 % of vessels. The presence of severe stenosis before PTCA, dissection, thrombus, multilesion PTCA, and template bleeding time values were not correlated with restenosis. Dilation of the left anterior descending (LAD) and a residual stenosis≥ 35 % were associated with restenosis.

Approximately 20% of the patients related difficulty in taking the fish oil. Furthermore, these results show no advantage over expected restenosis rates.

Angiology, Vol. 42, No. 3, 187-194 (1991)
DOI: 10.1177/000331979104200302
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