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Hemorheologic and Coagulative Pattern in Hypercholesterolemic Subjects Treated with Lipid-Lowering Drugs

Institute of Gerontology, University of Turin, Turin, Italy

F. Bonino

Institute of Gerontology, University of Turin, Turin, Italy

M. Neirotti

Institute of Gerontology, University of Turin, Turin, Italy

M. Gottero

Institute of Gerontology, University of Turin, Turin, Italy

L. Pernigotti

Institute of Gerontology, University of Turin, Turin, Italy

M. Molaschi

Institute of Gerontology, University of Turin, Turin, Italy

F. Fabris

Institute of Gerontology, University of Turin, Turin, Italy

The effects on the coagulative and rheologic pattern of two lipid-lowering drugs, bezafibrate and simvastatin, were studied in 36 hypercholesterolemic subjects. Patients were randomly divided into two groups (18 subjects each) and received bezafibrate R 400 mg/day or simvastatin 10-40 mg/day over a twelve week period. Besides a decrease in plasma fibrinogen and fibrinopeptide A (p<0.001 both), bezafibrate induced a reduction of factor VIIc and VIIIc activity (p<0.001 both), while antithrombin 3 activity was increased (p<0.001) and the hemorheologic pattern was greatly improved (p<0.001). Simvastatin caused a slight decrease in factor VIIIc activity and a moderate reduction of beta thromboglobulin. The efficacy of bezafibrate in reducing the activation of the coagulative cascade and improving the hemorheologic pattern has been con firmed; the peculiar triglycerides- and fibrinogen-lowering effect of the drug, not observed with simvastatin, could be responsible for these modifications.

Angiology, Vol. 42, No. 2, 106-113 (1991)
DOI: 10.1177/000331979104200204


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