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Detection of Deep Vein Thrombosis: Combined Flow and Blood Pool Radionuclide Venography vs Contrast Venography

Department of Nuclear Medicine, University Medical School

Mustafa Ozmen

Radiology, Hacettepe University Medical School, Ankara, Turkey

Alp Dincer

Radiology, Hacettepe University Medical School, Ankara, Turkey

Ozlem Kapucu

Department of Nuclear Medicine, University Medical School

Coskun Bekdik

Department of Nuclear Medicine, University Medical School

This study was performed to validate the combined study of flow radionuclide venography (FRV) with subsequent 99m Tc-red blood cell(RBC) blood pool ra dionuclide venography(BRV) for the detection of deep vein thrombosis (DVT). Findings in 32 patients with suspected DVT of lower extremities (n = 52) were compared with those of corresponding contrast venograms (CV) serving as a refer ence method. FRV was performed by using three separate doses of a large ^99mTc04-bolus (10-12 cc) injection. The findings were as follows: concerning the detection of DVT in calf veins, agreement between FRV and CV, FRV ^$BRV and CV, and BRV and CV were 67%, 73% and 60%, respectively. For femoral veins, agreement between FRV and CV was 96%, while it was 87% between BRV and CV. When FRV and BRV of femoral veins were evaluated in combination, 100% agreement between radionuclide and radiologic methods was observed. For ili ac veins there was no disagreement in comparison of the methods either singly or in combination. In 7.6% of the extremities, collaterals not demonstrated by CV and BRV were visualized only by FRV. Although the radioactive agent was injected in a relatively large volume, all of the calf veins could not be filled even when they were completely patent. It was concluded that a combined study of FRV with BRV improved the diagnostic value of radionuclide venography for the detection of DVT in calf and femoral veins.

Angiology, Vol. 42, No. 10, 796-804 (1991)
DOI: 10.1177/000331979104201004


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